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Debilitating chronic diarrhoea with resistant ascites: a case of lupus protein-losing enteropathy

Authors:

Lilanthi Padmika Subasinghe ,

National Hospital Sri Lanka, LK
About Lilanthi
Registrar - General Medicine
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N.I.C. Perera,

National Hospital Sri Lanka, LK
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G.A. Ratnatilaka

National Hospital Sri Lanka, LK
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Abstract

Gastrointestinal manifestations occur in approximately 25 to 40 percent of patients with systemic lupus erythematosus (SLE)1. Protein-losing enteropathy (PLE) in SLE, termed lupus protein-losing enteropathy (LUPLE),is a well-recognized clinical entity which is increasingly being noted in a number of case reports both locally and internationally2,3. PLE is characterized by excessive loss of serum proteins from the gastrointestinal mucosa which subsequently leads to significant hypoalbuminaemia1. Recently it is being frequently identified as the presenting feature of SLE2,3. Ascites in SLE commonly occurs as a consequence of its complications such as PLE, nephrotic syndrome, constrictive pericarditis and Budd–Chiari syndrome as well as a part of the disease itself in the forms of acute and chronic lupus peritonitis6. We report a rare case of a Sri Lankan female extensively investigated for long term recurrent diarrhoea, vomiting and gradual onset massive ascites who was ultimately diagnosed to have SLE associated PLE and lupus enteritis.

How to Cite: Subasinghe, L.P., Perera, N.I.C. & Ratnatilaka, G.A., (2015). Debilitating chronic diarrhoea with resistant ascites: a case of lupus protein-losing enteropathy. Journal of the Postgraduate Institute of Medicine. 2, pp.E13:1–E13:3. DOI: http://doi.org/10.4038/jpgim.7897
Published on 06 May 2015.
Peer Reviewed

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